Research Articles and Reviews

Updated: 2024-09-20 06:20:05

54. Y. Liu, Z. Zhu, Y. Zhang, Y. Zhang, S. Liu*, X. Shen*. "Stereoselective Synthesis of Silyl Enol Ethers with Acylsilanes and α,β-Unsaturated Ketones." Org.Lett. 2024. DOI: https://doi.org/10.1021/acs.orglett.4c01782.

53. Y. Zhang, X. Shen*. ''Photothermal cascade metathesis and cyclization.'' Trends Chem. 2024, DOI: 10.1016/j.trechm.2024.02.003

52. G. Zhou^#, Z. Guo^#, S. Liu, X. Shen*. ''Divergent Synthesis of Fluoroalkyl Ketones through Controlling the Reactivity of Organoboronate Complexes.'' J. Am. Chem. Soc. 2024, 146, 6, 4026–4035. (# contributed equally).

51. S. Deng, C. Peng, Y. Niu, Y. Xu, Y. Zhang, X. Chen, H. Wang, S. Liu, X. Shen*. ''Radical Brook Rearrangement Mediated Olefin Difunctionalization with α-Fluoroalkyl-α-silyl Methanols.'' Acta Chimica Sinica, 2024, 82(2): 119-125. (Invited contribution to Special Collection “有机氟化学”)

50. Y. Zhang, J. Wang, Y. Guo, S. Liu, X. Shen*. "Carbonyl Olefin Metathesis and Dehydrogenative Cyclization of Aromatic Ketones and gem-Difluoroalkenes." Angew. Chem. Int. Ed. 2023, e202315269.

49. Y. Guo, G. Zhou, X. Shen*. "Synthesis of organofluorine compounds with acylsilanes."Chin. J. Chem., 42: 887-902. (Invited review, Celebrating the 130th Anniversary of Wuhan University).

48. Z. Li^#, X. Chen^#, C. Peng, Y. Xu, H. Wang, S. Liu, X. Shen*. ''Merging Radical Brook Rearrangement and 1,5-Hydrogen Atom Transfer: Facile Synthesis of Ketone-Containing ɑ-Fluoroalkyl Alcohols.'' ChemCatChem 2023, e202301075. (# contributed equally; invited contribution to Special Collection “ChineseCatChem”).

47. C. Jin^#, X. He^#, S. Chen, Z. Guo, Y. Lan*, X. Shen*. "Axial Chirality Reversal and Enantioselective Access to Si-stereogenic Silylallene"  Chem 2023, 9, 2956-2970. (# contributed equally).

46. S. Chen, Y. Zhang, S. Liu, X. Shen*. ''Photocatalyzed [2+1] Cyclization of Alkenes and Silylated Trifluorodiazoethanes: Facile Entry into (Difluoromethylene)cyclopropanes'' Sci. China Chem 2023, 66, 3141–3147. (Invited contribution to Speal Issue: Celebrating the 130th Anniversary of Wuhan University).

45. Z. Li, Y. Zhang, Y. Zhang, X. He, X. Shen*. "Diastereoselective Synthesis of Monofluorocyclohexenes through Photocatalyzed Cascade Cyclization of gem-Difluoroalkenes and α,β-Unsaturated Carbonyl Compounds" Angew. Chem. Int. Ed. 2023, 62, e202303218.

44. S. Chen, X. Shen* . ''Nickel-Catalyzed Enantioselective Hydrosilylation of 1,1-Disubstituted Allenes'' Chinese J. Org. Chem. 2023, 43(3), 1213-1214. (Invited Highlight).

43. W. Zhang, S. Chen, X. Shen*. ''Nickel-Catalyzed [4+2] Cyclization of Benzosilacyclobutenes and Acylsilanes'' Chinese J. Org. Chem. 2023. DOI: 10.6023/cjoc202304035. (Invited contribution to Special Collection“有机硅化学”).

42. G. Zhou^#, Z. Guo^#, X. Shen*. "Electron-Rich Oxycarbenes: New Synthetic and Catalytic Applications beyond Group 6 Fischer Carbene Complexes" Angew. Chem. Int. Ed. 2023, 62, e202217189.

41. Y. Zhang^#, Y. Zhang^#, C. Ye, X. Qi*, L.-Z. Wu*, X. Shen*. ''Cascade Cyclization of Alkene-tethered Acylsilanes and Allylic Sulfones Enabled by Unproductive Energy Transfer Photocatalysis'' Nat. Commun. 2022, 13, 6111. (# contributed equally).

40. S. Chen, X. He, C. Jin, W. Zhang, Y. Yang, S. Liu, Y. Lan*, K. N. Houk*, X. Shen*. "Nickel-Catalyzed Cross-Redistribution between Hydrosilanes and Silacyclobutanes"  Angew. Chem. Int. Ed. 2022, 61, e202213431.

39. Y. Zhang^#, Y. Niu^#, Y. Guo, J. Wang, Y. Zhang, S. Liu, X. Shen*. "Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes" Angew. Chem. Int. Ed. 2022, 61, e202212201 . (# contributed equally).

38. P. Jin, X. Shen*. "SulfoxFluor as a deoxyfluorination reagent, and beyond" J. Fluorine Chem. 2022, 261-262, 110029.

37. Z. Zhu, W. Zhang, Y. Zhang, S. Liu, X. Shen*. ''Visible-Light-Induced [4+1] Cyclization-Aromatization of Acylsilanes and ɑ, β-Unsaturated Ketones'' CCS Chem. 2023, 5, 325-333.

36. S. Chen, X. He, Y. Jin, Y. Lan*, X. Shen*. ''Copper-Catalyzed Regio- and Stereo-Selective Hydrosilylation of Terminal Allenes to Access (E)-Allylsilanes'' Nat. Commun. 2022, 13 (1), 3691.

35. G. Zhou, X. Shen*. ''Visible-Light-Induced Organocatalyzed [2+1] Cyclization of Alkynes and (Trifluoroacetyl)silanes'' Synlett 2022, 33(16), 1575-1581. (Invited Synpacts).

34. Y. Zhang^#, G. Zhou^#, X. Gong^#, Z. Guo, X. Qi*, X. Shen*. ''Diastereoselective Transfer of Tri(di)fluoroacetylsilanes-Derived Carbenes to Alkenes'' Angew. Chem. Int. Ed. 2022, 61, e202202175. (# contributed equally).

33. Y. Zhang, Y. Zhang, Y. Guo, S. Liu, X. Shen*. ''Reductive Quenching-Initiated Catalyst-Controlled Divergent Alkylation of α-CF₃-Olefin'' Chem Catalysis 2022, 2 (6), 1380-1393.

32. X. He, Y. Zhao, Z. Zhang, X. Shen*. "Tuning the Reactivity of Alkoxyl Radicals from Cyclization to 1,2-Silyl Transfer: Stereoselective Synthesis of β-Substituted Cycloalcohols" Org. Lett. 2022, 24, 1991-1995.

31. X. Fang^#, W. Wen^#, P. Jin, W. Bao, S. Liu, H. Cong, X. Shen*. ''Synthesis of Enantioenriched Fluorinated Enol Silanes Enabled by Asymmetric Reductive Coupling of Fluoroalkylacylsilanes and 1,3-Enynes and Brook Rearrangement'' Acs Catal. 2022, 12, 2150-2157. (# contributed equally).

30. G. Zhou, X. Shen*. ''Synthesis of Cyclopropenols Enabled by Visible-Light-Induced Organocatalyzed [2+1] Cyclization'' Angew. Chem. Int. Ed. 2022, 61, e202115334. (Highlighted by Synfacts)

29. X. Chen, Z. Zhu, S. Liu, Y.-H. Chen, X. Shen*. ''MnBr₂ catalyzed regiospecific oxidative Mizoroki-Heck type reaction'' Chin. Chem. Lett. 2022, 33 (5), 2391-2396. (Invited contribution to the special collection on “Fluorine Chemistry”.)

28. Z. Zhu, X. Chen, S. Liu, J. Zhang, X. Shen*. ''Synthesis of 1-Tri(di)fluoromethyl 1,4-Diketones Enabled by Radical Brook Rearrangement'' Eur. J. Org. Chem. 2021, 4927. (Invited contribution to the special collection on “Silicon Chemistry in Organic Synthesis” Selected as Very Important Paper by the Editor).

27. Y. Zhang, Y. Zhang, X. Shen*. ''Alkoxyl Radical-Mediated Synthesis of Functionalized Allyl tert-(Hetero)cyclobutanols and Their Ring-opening and Ring-expansion Functionalizations'' Chem Catal. 2021, 1(2), 423.

26. Z. Yang^#, Y. Niu^#, X. He, S. Chen, S. Liu, Z. Li, X. Chen, Y. Zhang, Y. Lan*, X. Shen*. ''Tuning the Reactivity of Alkoxyl Radicals from 1,5-Hydrogen Atom Transfer to 1,2-Silyl Transfer'' Nat. Commun. 2021, 12, 2131. (# contributed equally).

25. X. Chen^#, X. Gong^#, Z. Li, G. Zhou, Z. Zhu, W. Zhang, S. Liu, X. Shen*. "Direct transfer of tri- and di-fluoroethanol units enabled by radical activation of organosilicon reagents" Nat. Commun. 2020, 11, 2756. (# contributed equally; Highlighted by Synfacts).

24. Y. Zhang^#, Y. Chen^#, Z. Zhang, S. Liu, X. Shen*. "Synthesis of Stereodefined Trisubstituted Alkenyl Silanes Enabled by Borane Catalysis and Nickel Catalysis" Org. Lett. 2020, 3,970-975. (# contributed equally).

23. Y. Li, X. Chen, X. Chen, X. Shen*. "Organophosphine-Catalyzed [4C+X] Annulations" Molecules 2018, 23(11), 3022. （Invited contribution to the Special Issue Sustainable Synthesis）

22. X. Shen, T. T. Nguyen, M. J. Koh, D. Xu, A. W. H. Speed, R. R. Schrock, A. H. Hoveyda*.  "Kinetically E-Selective Macrocyclic Ring-closing Metathesis" Nature 2017, 541, 380-385.

1) Highlighted by Sciencedaily https://www.sciencedaily.com/releases/2017/01/170109134020.htm

2) Highlighted by X-mol: http://www.x-mol.com/news/4730

21. C. Xu^#, X. Shen^#, A. H. Hoveyda*. "In situ Methylene Capping: A General Strategy for Efficient Stereo-Retentive Catalytic Olefin Metathesis. The Concept, Methodological Implications and Applications to Synthesis of Biologically Active Compounds" J. Am. Chem. Soc. 2017, 139, 10919-10928.

20. C. Xu, Z. Liu, S. Torker, X. Shen, D. Xu, A. H. Hoveyda*. "Synthesis of Z- or E-Trisubstituted Allylic Alcohols and Ethers by Kinetically Controlled Cross-Metathesis with a Ru Catechothiolate Complex" J. Am. Chem. Soc. 2017, 139, 15640-15643.

19. Q. Liu, X. Shen, C. Ni, J. Hu*. "Stereoselective Carbonyl Olefination with Fluorosulfoximines: Facile Access to Z or E Terminal Monofluoroalkenes" Angew. Chem. Int. Ed. 2017, 56, 619-623.

18. F. Meng, X. Li, S. Torker, Y. Shi, X. Shen, A. H. Hoveyda*. "Catalytic Enantioselective 1,6-Conjugate Additions of Propargyl and Allyl groups" Nature 2016, 537, 387-393.

17. T. T. Nguyen, M. J. Koh, X. Shen, F. Romiti, R. R. Schrock, A. H. Hoveyda*. "Kinetically Controlled E-Selective Catalytic Olefin Metathesis" Science 2016, 352, 569-575.

16. N. W. Goldberg, X. Shen, J. Li, T. Ritter*. "AlkylFluor: Deoxyfluorination of Alcohols" Org. Lett. 2016, 18, 6102-6104.

15. X. Shen, Q. Liu, W. Zhang, J. Hu*. "Stereoselective Synthesis of (Sulfonimidoyl)cyclopropanes with (R)-PhSO(NTs)CH₂Cl and α,β-Unsaturated Weinreb Amides: Tuning the of Selectivity between C–Cl and C–S Bond Cleavage" Eur. J. Org. Chem. 2016, 906-909.

14. X. Shen, C. N. Neumann, C. Kleinlein, N. W. Goldberg, T. Ritter*. "Alkyl Aryl Ether Bond Formation with PhenoFluor" Angew. Chem. Int. Ed. 2015, 54, 5662-5665.

13. T. Luo, R. Zhang, X. Shen, W. Zhang, C. Ni, J. Hu*. "Brønsted acid-catalyzed 1,2-fluorine migration with fluoroepoxides" Dalton Trans. 2015, 44, 19636-19641.

12. X. Shen, W. Miao, C. Ni, J. Hu*. "Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral α-Fluoro Carbanions" Angew. Chem. Int. Ed. 2014, 53, 775-779.

11. X. Shen, M. Zhou, C. Ni, W. Zhang, J. Hu*. "Direct Monofluoromethylation of O-, S-, N-, and P-Nucleophiles with PhSO(NTs)CH₂F: Accelerating Effect of α-Fluorine Substitution" Chem. Sci. 2014, 5, 117-122.

10. X. Shen, Q. Liu, T. Luo, J. Hu*. "Nucleophilic Difluoromethylation of Epoxides with PhSO(NTBS)CF2H by a Preorganization Strategy" Chem. Eur. J. 2014, 20, 6795-6800.

9. X. Shen, J. Hu*. "Fluorinated Sulfoximines: Preparation, Reactions and Applications" Eur. J. Org. Chem. 2014, 4437-4451.

8. X. Shen, Q. Liu, C. Ni, J. Hu*. "Nucleophilic Difluoro(phenylsulfonimidoyl)- methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF₂H: Facile Entry into gem-Difluoroalkenes" Chin. J. Chem. 2014, 32, 703-708. (Dedicated to Professor Chengye Yuan and Professor Li-Xin Dai on the occasion of their 90th birthdays.)

1) Cover picture: https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.201490017

7. T. Luo, R. Zhang, W. Zhang, X. Shen, T. Umemoto, J. Hu*. "Divergent Rearrangements of Cyclopropyl-Substituted Fluoroepoxides Involving C–F Bond Cleavage and Formation" Org. Lett. 2014, 16, 888-891.

6. Y. Zhao, C. Ni, F. Jiang, B. Gao, X. Shen, J. Hu*. "Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)sulfonyl Group" Acs Catal. 2013, 3, 631-634.

5. X. Shen, C. Ni, J. Hu*. "Highly Stereoselective and One-Pot Synthesis of Tetra-substituted Monofluoroalkenes with Aldehydes and Fluorobis(phenylsulfonyl)methane" Chin. J. Chem. 2013, 31, 878-884.

4. X. Shen, W. Zhang, C. Ni, Y. Gu, J. Hu*. "Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones" J. Am. Chem. Soc. 2012, 134, 16999-17002.

3. X. Shen, W. Zhang, L. Zhang, T. Luo, X. Wan, Y. Gu, J. Hu*. "Enantioselective Synthesis of Cyclopropanes That Contain Fluorinated Tertiary Stereogenic Carbon Centers: A Chiral α-Fluoro Carbanion Strategy" Angew. Chem. Int. Ed. 2012, 51, 6966-6970.

2. X. Shen, C. Ni, J. Hu*. "Nucleophilic Fluoroalkylation of α,β-Unsaturated Carbonyl Compounds with α-Fluorinated Sulfones: Investigation of the Rever-sibility of 1,2-Additions and the Formation of 1,4-Adducts" Helv. Chim. Acta, 2012, 95, 2043-2051. (Dedicated to Professor Dieter Seebach on the occasion of his 75th birthday).

1. X. Shen, L. Zhang, Y. Zhao, L. Zhu, G. Li, J. Hu*. "Nucleophilic Fluoromethylation of Aldehydes with Fluorobis(phenylsulfonyl)methane: The Importance of Strong Li-O Coordination and Fluorine Substitution for C-C Bond Formation" Angew. Chem. Int. Ed. 2011, 50, 2588-2592.